2021 Puerto Vallarta Open

The 2021 Puerto Vallarta Open was a professional tennis tournament played on hard courts. It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Puerto Vallarta, Mexico between 22 and 28 November 2021.

Seeds

 * 1 Rankings are as of 15 November 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇺🇸 Milledge Cossu
 * 🇲🇽 Gerardo López Villaseñor
 * 🇨🇳 Shang Juncheng

The following players received entry into the singles main draw using protected rankings:
 * 🇺🇸 Alexander Sarkissian
 * 🇳🇿 Rubin Statham

The following players received entry into the singles main draw as alternates:
 * Martín Cuevas
 * 🇦🇷 Matías Franco Descotte

The following players received entry from the qualifying draw:
 * 🇨🇦 Liam Draxl
 * 🇲🇽 Alex Hernández
 * 🇺🇸 Christian Langmo
 * 🇺🇸 Govind Nanda

Singles

 * 🇩🇪 Daniel Altmaier def. Alejandro Tabilo 6–3, 3–6, 6–3.

Doubles

 * Gijs Brouwer / 🇺🇸 Reese Stalder def. 🇲🇽 Hans Hach Verdugo / 🇲🇽 Miguel Ángel Reyes-Varela 6–4, 6–4.