2021 Purdue Fort Wayne Mastodons baseball team

The 2021 Purdue Fort Wayne Mastodons baseball team was a baseball team that represented Purdue University Fort Wayne in the 2021 NCAA Division I baseball season. The Mastodons were members of the Horizon League and play their home games at Mastodon Field in Fort Wayne, Indiana. They were led by second-year head coach Doug Schreiber.

Previous season
The Mastodons finished the 2020 NCAA Division I baseball season 5–10 overall (0–0 conference) and tied for first place in conference standings. The season was cut short in stages by March 12, 2020 due to the COVID-19 pandemic.

Preseason Horizon poll
For the 2021 poll, Purdue Fort Wayne was projected to finish in fifth in the Conference.

Schedule
! style="" | Regular season
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