2021 Qatar Total Open – Singles

Petra Kvitová defeated Garbiñe Muguruza in the final, 6–2, 6–1 to win the singles tennis title at the 2021 WTA Qatar Open. The final was a rematch of the 2018 final. It was Kvitová's second title at the WTA Qatar Open. Kvitová dropped just one set the entire tournament, to Anett Kontaveit in the quarterfinals.

Aryna Sabalenka was the defending champion, but lost in the second round to Muguruza.

Seeds
The top four seeds received a bye into the second round. • #🇺🇦 Elina Svitolina (quarterfinals)

• #🇨🇿 Karolína Plíšková (quarterfinals)

• #🇧🇾 Aryna Sabalenka (second round)

• #🇨🇿 Petra Kvitová (champion)

• # Kiki Bertens (first round)

• # Belinda Bencic (first round)

• #🇺🇸 Jennifer Brady (first round)

• #🇧🇾 Victoria Azarenka (semifinals, withdrew)

Seeds
• # 🇺🇸 Jessica Pegula (qualified)

• # 🇩🇪 Laura Siegemund (qualified)

• # 🇷🇴 Patricia Maria Țig (first round)

• # 🇨🇿 Barbora Krejčíková (second round)

• # 🇨🇿 Kateřina Siniaková (second round)

• # 🇷🇺 Anna Blinkova (qualified)

• # 🇨🇿 Kristýna Plíšková (qualified)

• # 🇯🇵 Misaki Doi (qualifying competition, lucky loser)

Qualifiers
• # 🇺🇸 Jessica Pegula

• # 🇩🇪 Laura Siegemund

• # 🇷🇺 Anna Blinkova

• # 🇨🇿 Kristýna Plíšková

Lucky loser

 * 1) 🇯🇵 Misaki Doi