2021 Quito Challenger – Singles

Nicolás Jarry was the defending champion but chose not to defend his title.

Facundo Mena won the title after defeating Gonzalo Lama 6–4, 6–4 in the final.

Seeds
• # 🇸🇰 Andrej Martin (first round)

• # 🇪🇨 Emilio Gómez (second round)

• # 🇪🇸 Mario Vilella Martínez (second round)

• # 🇦🇷 Renzo Olivo (second round)

• # 🇦🇷 Juan Pablo Ficovich (quarterfinals)

• # 🇦🇷 Facundo Mena (champion)

• # 🇦🇷 Thiago Agustín Tirante (quarterfinals)

• # 🇪🇨 Roberto Quiroz (second round)