2021 Rolex Paris Masters – Singles

Novak Djokovic defeated the defending champion Daniil Medvedev in the final, 4–6, 6–3, 6–3 to win the singles tennis title at the 2021 Paris Masters. It was his record-extending sixth Paris Masters title and record-breaking 37th ATP Tour Masters 1000 title overall, surpassing Rafael Nadal's tally in the latter category.

With his victory over Hubert Hurkacz in the semifinals, Djokovic also secured the year-end ATP No. 1 singles ranking for a record seventh time, breaking a tie with Pete Sampras in the process.

Seeds
The top eight seeds received a bye into the second round. • 🇷🇸 Novak Djokovic (champion)

• 🇷🇺 Daniil Medvedev (final)

• Stefanos Tsitsipas (second round, retired)

• 🇩🇪 Alexander Zverev (semifinals)

• 🇷🇺 Andrey Rublev (second round)

• 🇳🇴 Casper Ruud (quarterfinals)

• 🇵🇱 Hubert Hurkacz (semifinals)

• 🇮🇹 Jannik Sinner (second round)

• 🇨🇦 Félix Auger-Aliassime (second round)

• 🇬🇧 Cameron Norrie (third round)

• 🇦🇷 Diego Schwartzman (second round)

• 🇪🇸 Pablo Carreño Busta (second round)

• 🇷🇺 Aslan Karatsev (first round)

• 🇪🇸 Roberto Bautista Agut (first round)

• 🇫🇷 Gaël Monfils (third round, withdrew)

• 🇧🇬 Grigor Dimitrov (third round)

Seeds
• # 🇺🇸 Tommy Paul (qualified)

• # 🇪🇸 Pedro Martínez (first round)

• # 🇺🇸 Jenson Brooksby (qualified, withdrew)

• # 🇺🇸 Marcos Giron (qualified)

• # Kevin Anderson (first round)

• # 🇩🇪 Dominik Koepfer (qualifying competition, lucky loser)

• # 🇫🇷 Benjamin Bonzi (first round)

• # 🇮🇹 Lorenzo Musetti (qualifying competition, lucky loser)

• # 🇮🇹 Gianluca Mager (qualified)

• # 🇫🇮 Emil Ruusuvuori (withdrew)

• # 🇷🇸 Miomir Kecmanović (qualified)

• # 🇦🇷 Federico Coria (first round)

• # 🇦🇺 Alexei Popyrin (qualifying competition, lucky loser)

• # 🇪🇸 Roberto Carballés Baena (qualifying competition)

Qualifiers
• # 🇺🇸 Tommy Paul

• # 🇸🇪 Mikael Ymer

• # 🇺🇸 Jenson Brooksby

• # 🇺🇸 Marcos Giron

• # 🇫🇷 Hugo Gaston

• # 🇷🇸 Miomir Kecmanović

• # 🇮🇹 Gianluca Mager

Lucky losers
• # 🇮🇹 Lorenzo Musetti

• # 🇩🇪 Dominik Koepfer

• # 🇦🇺 Alexei Popyrin