2021 São Paulo FC season

The 2021 season is São Paulo's 92nd season in the club's history and their 61st in the top-flight of Brazilian football. Along with Série A, São Paulo will also compete in the Campeonato Paulista, Copa do Brasil and Copa Libertadores.

Retired numbers

 * 01 – 🇧🇷 Rogério Ceni, Goalkeeper (1990–2015)

Overall
{|class="wikitable"
 * Games played || 70 (16 Campeonato Paulista, 6 Copa do Brasil, 10 Copa Libertadores, 38 Campeonato Brasileiro)
 * Games won || 29 (11 Campeonato Paulista, 3 Copa do Brasil, 4 Copa Libertadores, 11 Campeonato Brasileiro)
 * Games drawn || 24 (4 Campeonato Paulista, 1 Copa do Brasil, 4 Copa Libertadores, 15 Campeonato Brasileiro)
 * Games lost || 17 (1 Campeonato Paulista, 2 Copa do Brasil, 2 Copa Libertadores, 12 Campeonato Brasileiro)
 * Goals scored || 101
 * Goals conceded || 68
 * Goal difference || +33
 * Best results (goal difference) || 9–1 (H) v 4 de Julho - Copa do Brasil - 2021.06.08
 * Worst result (goal difference)|| 1–5 (A) v Flamengo - Série A - 2021.07.25
 * Top scorer || Pablo (13 goals)
 * Goals conceded || 68
 * Goal difference || +33
 * Best results (goal difference) || 9–1 (H) v 4 de Julho - Copa do Brasil - 2021.06.08
 * Worst result (goal difference)|| 1–5 (A) v Flamengo - Série A - 2021.07.25
 * Top scorer || Pablo (13 goals)
 * Best results (goal difference) || 9–1 (H) v 4 de Julho - Copa do Brasil - 2021.06.08
 * Worst result (goal difference)|| 1–5 (A) v Flamengo - Série A - 2021.07.25
 * Top scorer || Pablo (13 goals)
 * Top scorer || Pablo (13 goals)
 * Top scorer || Pablo (13 goals)

Copa Libertadores
The draw for the group stage was held on 9 April 2021, 12:00 PYST (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.

Round of 16
The draw for the round of 16 was held on 1 June 2021.

Matches
The league fixtures were announced on 24 March 2021.