2021 Saint Louis Billikens baseball team

The 2021 Saint Louis Billikens baseball team represented Saint Louis University during the 2021 NCAA Division I baseball season. The Billikens played their home games at Billiken Sports Center as a members of the Atlantic 10 Conference. They were led by head coach Darin Hendrickson, in his 13th season at Saint Louis.

Previous season
The 2020 Saint Louis Billikens baseball team notched a 10–6 (0–0) regular season record. The season prematurely ended on March 12, 2020, due to concerns over the COVID-19 pandemic.

Coaches Poll
The Atlantic 10 baseball coaches' poll was released on February 18, 2021. Saint Louis was picked to finish fifth the Atlantic 10 regular season championship.