2021 Salinas Challenger – Singles

Víctor Estrella Burgos was the defending champion but chose not to defend his title.

Nicolás Jarry won the title after defeating Nicolás Mejía 7–6(9–7), 6–1 in the final.

Seeds
• # 🇯🇵 Yasutaka Uchiyama (first round, retired)

• # Alejandro Tabilo (first round)

• # 🇪🇨 Emilio Gómez (first round)

• # 🇺🇸 Christopher Eubanks (second round)

• # Marcelo Tomás Barrios Vera (quarterfinals)

• # 🇹🇷 Altuğ Çelikbilek (semifinals)

• # 🇯🇵 Hiroki Moriya (first round)

• # 🇪🇨 Roberto Quiroz (first round)