2021 Santa Cruz Futebol Clube season

The 2021 season was Santa Cruz's 108th season in the club's history. Santa Cruz competed in the Campeonato Pernambucano, Série C and Copa do Nordeste.

Overall
{| class="wikitable" 0–2 (A) v Altos – Copa do Nordeste – 2021.04.04 0–2 (H) v Sete de Setembro – Pernambucano – 2021.04.25 0–2 (A) v Manaus – Série C – 2021.05.30
 * Games played || 41 (10 Copa do Nordeste, 11 Pernambucano, 2 Copa do Brasil, 18 Série C)
 * Games won || 8 (2 Copa do Nordeste, 3 Pernambucano, 1 Copa do Brasil, 2 Série C)
 * Games drawn || 12 (1 Copa do Nordeste, 5 Pernambucano, 0 Copa do Brasil, 6 Série C)
 * Games lost || 21 (7 Copa do Nordeste, 3 Pernambucano, 1 Copa do Brasil, 10 Série C)
 * Goals scored || 35
 * Goals conceded || 44
 * Goal difference || –9
 * Best results (goal difference) || 4–0 (A) v Ypiranga – Copa do Brasil – 2021.03.26
 * Worst result (goal difference)|| 0–2 (A) v Vitória – Copa do Nordeste – 2021.02.27
 * Goals scored || 35
 * Goals conceded || 44
 * Goal difference || –9
 * Best results (goal difference) || 4–0 (A) v Ypiranga – Copa do Brasil – 2021.03.26
 * Worst result (goal difference)|| 0–2 (A) v Vitória – Copa do Nordeste – 2021.02.27
 * Best results (goal difference) || 4–0 (A) v Ypiranga – Copa do Brasil – 2021.03.26
 * Worst result (goal difference)|| 0–2 (A) v Vitória – Copa do Nordeste – 2021.02.27
 * Worst result (goal difference)|| 0–2 (A) v Vitória – Copa do Nordeste – 2021.02.27
 * Worst result (goal difference)|| 0–2 (A) v Vitória – Copa do Nordeste – 2021.02.27
 * Top scorer || Pipico (10)
 * Top scorer || Pipico (10)

Managers performance
(c) Indicates the caretaker manager