2021 Santos FC season

The 2021 season was Santos FC's 109th season in existence and the club's sixty-second consecutive season in the top flight of Brazilian football. As well as the Campeonato Brasileiro, the club competed in the Copa do Brasil, Campeonato Paulista and the Copa Libertadores.

Squad information
Source: SantosFC.com.br (for appearances and goals), Wikipedia players' articles (for international appearances and goals), FPF (for contracts). Players in italic were not registered for the Campeonato Paulista

Copa Libertadores squad

 * Players in strike were no longer in the squad until the team's last match (26 May)
 * Players in italic were included in the last submission

Source: Conmebol.com

Copa Sudamericana squad

 * Players in strike are no longer in the squad
 * Players in italic were included in the last submission

Source: Conmebol.com

Appearances and goals
Last updated: 10 December 2021

Source: Match reports in Competitive matches, Soccerway

Goalscorers
Last updated: 10 December 2021

Source: Match reports in Competitive matches

Disciplinary record
As of 10 December 2021 Source: Match reports in Competitive matches = Number of bookings; sent off: = Number of sending offs after a second yellow card; sent off:  = Number of sending offs by a direct red card.

Loans out

 * Notes

Copa Sudamericana
The draw for the final stage was held on 1 June 2021.