2021 TCU Horned Frogs baseball team

The 2021 TCU Horned Frogs baseball team represented Texas Christian University during the 2021 NCAA Division I baseball season. The Horned Frogs played their home games at Lupton Stadium as a member of the Big 12 Conference. They were led by head coach Jim Schlossnagle, in his 18th and final season at TCU.

Previous season
The 2020 TCU Horned Frogs baseball team notched an 11–4 record in February and early March; however, the remainder of the season was abruptly halted on March 13, 2020, when the Big 12 Conference canceled the remainder of the athletics season due to the Coronavirus pandemic.

Schedule and results
! style="" | Regular Season (34–12)
 * - valign="top"


 * Legend:      = Win       = Loss       = Canceled      Bold = TCU team member
 * "*" indicates a non-conference game. "#" represents ranking. All rankings from D1Baseball on the date of the contest. "" represents postseason seeding in the Big 12 Tournament or NCAA Regional, respectively.
 * "*" indicates a non-conference game. "#" represents ranking. All rankings from D1Baseball on the date of the contest. "" represents postseason seeding in the Big 12 Tournament or NCAA Regional, respectively.