2021 Tali Open – Singles

Emil Ruusuvuori was the defending champion but withdrew from the tournament before his first round match.

Alex Molčan won the title after defeating João Sousa 6–3, 6–2 in the final.

Seeds
• # 🇫🇮 Emil Ruusuvuori (withdrew)

• # Henri Laaksonen (semifinals)

• # 🇸🇰 Alex Molčan (champion)

• # 🇧🇾 Egor Gerasimov (first round)

• # 🇩🇪 Oscar Otte (quarterfinals)

• # 🇬🇧 Liam Broady (quarterfinals)

• # 🇸🇰 Jozef Kovalík (first round)

• # 🇷🇸 Nikola Milojević (quarterfinals)