2021 Tenerife Ladies Open – Singles

This was the first edition of the tournament.

Ann Li won her maiden WTA title, defeating Camila Osorio in the final, 6–1, 6–4. This was Li's second final of the year, but the first in which she was able to compete; the Grampians Trophy final in February was cancelled due to scheduling difficulties.

Seeds
• #🇺🇦 Elina Svitolina (first round)

• # Tamara Zidanšek (first round)

• #🇪🇸 Sara Sorribes Tormo (first round)

• #🇮🇹 Camila Giorgi (semifinals)

• # Viktorija Golubic (first round)

• #🇨🇳 Zhang Shuai (first round)

• # Clara Tauson (second round)

• #🇺🇸 Alison Riske (first round)

Seeds
• # Kaja Juvan (qualifying competition, lucky loser)

• # Donna Vekić (qualified)

• # 🇷🇴 Jaqueline Cristian (qualified)

• # 🇨🇳 Wang Xinyu (qualified)

• # Stefanie Vögele (qualified)

• # 🇭🇺 Dalma Gálfi (qualifying competition)

• # 🇧🇪 Kirsten Flipkens (qualifying competition)

• # 🇭🇺 Anna Bondár (qualifying competition)

• # 🇧🇪 Ysaline Bonaventure (qualifying competition)

• # Lesley Pattinama Kerkhove (qualifying competition)

• # 🇪🇸 Aliona Bolsova (qualified)

• # 🇮🇳 Ankita Raina (first round)

Qualifiers
• # 🇪🇸 Aliona Bolsova

• # Donna Vekić

• # 🇷🇴 Jaqueline Cristian

• # 🇨🇳 Wang Xinyu

• # Stefanie Vögele

• # 🇱🇺 Mandy Minella

Lucky loser
• # Kaja Juvan