2021 Tennis Napoli Cup

The 2021 Tennis Napoli Cup was a professional tennis tournament played on clay courts. It was the 20th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Naples, Italy between 4 and 10 October 2021.

Seeds

 * 1 Rankings as of 27 September 2021.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇮🇹 Matteo Arnaldi
 * 🇮🇹 Jacopo Berrettini
 * 🇮🇹 Luca Nardi

The following player received entry into the singles main draw using a protected ranking:
 * 🇮🇹 Filippo Baldi

The following player received entry into the singles main draw as an alternate:
 * 🇷🇸 Miljan Zekić

The following players received entry from the qualifying draw:
 * 🇷🇴 Bogdan Ionuț Apostol
 * 🇮🇹 Raúl Brancaccio
 * 🇮🇹 Marco Miceli
 * 🇮🇹 Julian Ocleppo

The following players received entry as lucky losers:
 * 🇷🇴 Alexandru Jecan
 * Petros Tsitsipas

Singles

 * Tallon Griekspoor def. 🇮🇹 Andrea Pellegrino 6–3, 6–2.

Doubles

 * 🇩🇪 Dustin Brown / 🇮🇹 Andrea Vavassori def. 🇧🇦 Mirza Bašić / Nino Serdarušić 7–5, 7–6(7–5).