2021 Texas Southern Tigers football team

The 2021 Texas Southern Tigers football team represented Texas Southern University a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2021 NCAA Division I FCS football season. Led third-year head coach Clarence McKinney, the Tigers compiled an overall record of 2–8 with a mark of 2–6 in conference play, placing fifth in the SWAC's West Division. Texas Southern played home games at BBVA Compass Stadium in Houston.

Texas Southern's game against on October 2 was considered an exhibition game.