2021 Trofeo Faip–Perrel – Singles

There was no defending champion as the final of the previous edition was canceled due to the coronavirus pandemic.

Holger Rune won the title after defeating Cem İlkel 7–5, 7–6(8–6) in the final.

Seeds
• # 🇸🇰 Alex Molčan (semifinals)

• # 🇦🇹 Dennis Novak (quarterfinals)

• # Holger Rune (champion)

• # 🇲🇩 Radu Albot (second round)

• # 🇬🇧 Liam Broady (quarterfinals)

• # 🇨🇿 Zdeněk Kolář (quarterfinals)

• # 🇷🇸 Nikola Milojević (first round)

• # 🇧🇦 Damir Džumhur (quarterfinals)