2021 USL League Two Playoffs

The 2021 USL League Two Playoffs was the post-season championship for the 2021 USL League Two season. It is the twenty-sixth edition of the Playoffs and the second under the USL League Two banner. The playoffs began on July 16 and ended with the USL League Two Final on July 31.

There were no playoffs the previous season due to the COVID-19 pandemic.

The Des Moines Menace won their third straight Regular Season Title (2018, 2019, 2021), with an average of 2.75 standings points per game.

The Menace defeated North Carolina Fusion U23 in the National Final 1–0 before a record crowd of 7,342.

Eastern Conference
Northeast Division
 * Western Mass Pioneers - Division Winner
 * Boston Bolts - Division Runner-up
 * Seacoast United Phantoms - Conference Wild Card (Best 3rd place record between the Mid Atlantic and Northeast Divisions)

Mid Atlantic Division
 * West Chester United SC - Division Winner
 * Ocean City Nor'easters - Division Runner-up

Metropolitan Division
 * Long Island Rough Riders - Division Winner
 * Cedar Stars Rush - Division Runner-up
 * New York Red Bulls U-23 - Division 3rd Place

Southern Conference
South Atlantic Division
 * North Carolina Fusion U23 - Division Winner
 * Lionsbridge FC - Division Runner-up
 * West Virginia United - Division 3rd Place

Deep South Division
 * SC United Bantams - Division Winner
 * Tormenta FC 2 - Division Runner-up
 * East Atlanta FC - Division 3rd Place

Southeast Division
 * The Villages SC - Division Winner
 * Tampa Bay United - Division Runner-up

Central Conference
Great Lakes Division
 * Kalamazoo FC - Division Winner
 * Flint City Bucks - Division Runner-up
 * Kings Hammer FC - Division 3rd Place

Heartland Division
 * Des Moines Menace - Division Winner
 * Chicago FC United - Division Runner-up

Mid South Division
 * Mississippi Brilla FC - Division Winner
 * Corpus Christi FC - Division Runner-up
 * Texas United - Division 3rd Place

Western Conference
Mountain Division
 * Park City Red Wolves - Division Winner

Northwest Division
 * Portland Timbers U23s - Division Winner

Southwest Division
 * Teams did not participate in the 2021 season due to COVID-19 concerns.

Final
Championship MVP: Manel Busquets (DMM)