2021 US Open – Boys' doubles

Eliot Spizzirri and Tyler Zink were the defending champions, having won the previous edition in 2019, however both players were no longer eligible to participate in junior events. Spizzirri and Zink received a wildcard in the men's doubles event, where they lost in the first round.

Max Westphal and Coleman Wong won the title, defeating Viacheslav Bielinskyi and Petr Nesterov in the final, 6–3, 5–7, [10–1].

Seeds
All seeds received a bye into the second round. • # Jérôme Kym / 🇬🇧 Jack Pinnington Jones (withdrew)

• # 🇺🇸 Samir Banerjee / 🇺🇸 Ozan Colak (second round)

• # 🇫🇷 Sean Cuenin / 🇫🇷 Sascha Gueymard Wayenburg (quarterfinals)

• # 🇺🇸 Alexander Bernard / 🇺🇸 Dali Blanch (second round)

• # 🇵🇪 Gonzalo Bueno / Adolfo Daniel Vallejo (second round)

• # 🇺🇸 Victor Lilov / 🇸🇰 Peter Benjamín Privara (quarterfinals)

• # 🇪🇸 Daniel Rincón / 🇯🇴 Abedallah Shelbayh (second round)

• # 🇺🇦 Viacheslav Bielinskyi / 🇧🇬 Petr Nesterov (final)