2021 US Open – Wheelchair men's doubles

Four-time defending champions Alfie Hewett and Gordon Reid defeated Gustavo Fernández and Shingo Kunieda in the final, 6–2, 6–1 to win the men's doubles wheelchair tennis title at the 2021 US Open. With the win, they became the first men's doubles wheelchair team to complete the Grand Slam.

Seeds
• #🇬🇧 Alfie Hewett / 🇬🇧 Gordon Reid (champions)

• #🇫🇷 Stéphane Houdet / 🇫🇷 Nicolas Peifer (semifinals)