2021 US Open – Wheelchair men's singles

Defending champion Shingo Kunieda defeated Alfie Hewett in the final, 6–1, 6–4 to win the men's singles wheelchair tennis title at the 2021 US Open. It was his eighth US Open singles title and 25th major singles title overall.

Seeds
• #🇯🇵 Shingo Kunieda (champion)

• #🇬🇧 Alfie Hewett (final)