2021 US Open – Wheelchair women's doubles

Diede de Groot and Aniek van Koot defeated the defending champions Yui Kamiji and Jordanne Whiley in the final, 6–1, 6–2 to win the women's doubles wheelchair tennis title at the 2021 US Open.

Seeds
• # Diede de Groot / Aniek van Koot (champions)

• #🇯🇵 Yui Kamiji / 🇬🇧 Jordanne Whiley (final)