2021 Uruguay Open – Doubles

Facundo Bagnis and Andrés Molteni were the defending champions but chose not to defend their title.

Rafael Matos and Felipe Meligeni Alves won the title after defeating Ignacio Carou and Luciano Darderi 6–4, 6–4 in the final.

Seeds
• # 🇧🇷 Rafael Matos / 🇧🇷 Felipe Meligeni Alves (champions)

• # Marcelo Tomás Barrios Vera / Alejandro Tabilo (withdrew)

• # 🇦🇷 Tomás Martín Etcheverry / 🇦🇷 Renzo Olivo (semifinals, withdrew)

• # 🇦🇷 Francisco Cerúndolo / Martín Cuevas (semifinals)