2021 Uruguay Open – Singles

Jaume Munar was the defending champion but lost in the semifinals to Juan Ignacio Londero.

Hugo Dellien won the title after defeating Londero 6–0, 6–1 in the final.

Seeds
• # 🇦🇷 Federico Coria (semifinals)

• # 🇪🇸 Jaume Munar (semifinals)

• # 🇦🇷 Facundo Bagnis (quarterfinals, retired)

• # 🇧🇷 Thiago Monteiro (quarterfinals)

• # 🇦🇷 Francisco Cerúndolo (first round)

• # 🇵🇪 Juan Pablo Varillas (second round)

• # 🇧🇴 Hugo Dellien (champion)

• # 🇦🇷 Tomás Martín Etcheverry (second round)