2021 Volvo Car Open – Singles

Veronika Kudermetova defeated Danka Kovinić in the final, 6–4, 6–2, to win the singles tennis title at the 2021 Charleston Open. Kudermetova did not drop a set en route to her first career Women's Tennis Association (WTA) singles title.

Madison Keys was the defending champion, but she lost in the second round to Sloane Stephens in a rematch of the previous tournament's quarterfinal. As all losing quarterfinalists were previous WTA title holders, all four semifinalists were in contention to become a maiden WTA champion.

Seeds
The top eight seeds received a bye into the second round. • 🇦🇺 Ashleigh Barty (quarterfinals)

• 🇺🇸 Sofia Kenin (second round)

• 🇨🇿 Petra Kvitová (third round)

• Kiki Bertens (withdrew)

• Belinda Bencic (second round)

• 🇪🇸 Garbiñe Muguruza (third round, retired)

• 🇧🇪 Elise Mertens (second round)

• 🇺🇸 Madison Keys (second round)

• 🇨🇿 Markéta Vondroušová (withdrew)

• 🇰🇿 Elena Rybakina (first round, retired)

• 🇰🇿 Yulia Putintseva (quarterfinals)

• 🇹🇳 Ons Jabeur (semifinals)

• 🇺🇸 Amanda Anisimova (second round)

• 🇺🇸 Coco Gauff (quarterfinals)

• 🇷🇺 Veronika Kudermetova (champion)

• 🇨🇳 Zhang Shuai (first round)

• 🇨🇿 Marie Bouzková (second round)

Seeds
• # 🇬🇧 Harriet Dart (qualifying competition, lucky loser)

• # 🇸🇰 Kristína Kučová (first round, retired)

• # 🇨🇳 Wang Xinyu (qualifying competition, lucky loser)

• # 🇷🇺 Natalia Vikhlyantseva (qualified)

• # 🇺🇸 Caroline Dolehide (qualifying competition, lucky loser)

• # 🇺🇸 Whitney Osuigwe (qualifying competition, lucky loser)

• # 🇵🇱 Magdalena Fręch (qualified)

• # 🇯🇵 Kurumi Nara (qualified)

• # 🇷🇺 Varvara Flink (first round)

• # 🇺🇸 Allie Kiick (qualifying competition)

• # 🇦🇺 Storm Sanders (qualified)

• # 🇺🇸 Asia Muhammad (qualified)

• # 🇷🇴 Gabriela Talabă (qualified)

• # 🇺🇸 Grace Min (qualified)

• # 🇦🇺 Ellen Perez (first round)

• # 🇺🇦 Kateryna Bondarenko (qualifying competition)

Qualifiers
• # 🇺🇸 Grace Min

• # 🇺🇸 Desirae Krawczyk

• # 🇷🇴 Gabriela Talabă

• # 🇷🇺 Natalia Vikhlyantseva

• # 🇦🇺 Storm Sanders

• # 🇺🇸 Asia Muhammad

• # 🇵🇱 Magdalena Fręch

• # 🇯🇵 Kurumi Nara

Lucky losers
• # 🇨🇳 Wang Xinyu

• # 🇬🇧 Harriet Dart

• # 🇺🇸 Caroline Dolehide

• # 🇺🇸 Whitney Osuigwe