2021 WTA German Open – Singles

Liudmila Samsonova defeated Belinda Bencic in the final, 1–6, 6–1, 6–3, to win the singles tennis title at the 2021 WTA German Open. Samsonova was contesting her first career final on the WTA Tour and had entered the main draw as a qualifier. Her win made her the 10th maiden titlist on the 2021 WTA Tour and the second qualifier of the season to claim a title.

Dinara Safina was the defending champion from when the event was last held in 2008 on clay courts, but she retired from professional tennis in 2014. As the inaugural edition of the tournament following its relaunch, this marked the first year the tournament was played on grass.

Seeds
• #🇧🇾 Aryna Sabalenka (second round)

• #🇺🇦 Elina Svitolina (second round)

• #🇨🇦 Bianca Andreescu (second round)

• #🇨🇿 Karolína Plíšková (second round)

• # Belinda Bencic (final)

• #🇪🇸 Garbiñe Muguruza (quarterfinals)

• #🇧🇾 Victoria Azarenka (semifinals)

• #🇨🇿 Karolína Muchová (first round)

Seeds
• # 🇺🇸 Ann Li (first round)

• # 🇷🇺 Anna Blinkova (first round)

• # 🇯🇵 Misaki Doi (qualified)

• # Kaja Juvan (first round)

• # 🇧🇾 Aliaksandra Sasnovich (first round)

• # 🇷🇺 Liudmila Samsonova (qualified)

• # 🇩🇪 Anna-Lena Friedsam (qualifying competition)

• # 🇺🇸 Claire Liu (qualifying competition)

• # Stefanie Vögele (qualifying competition)

• # Ana Konjuh (qualifying competition)

• # 🇩🇪 Tamara Korpatsch (first round)

• # 🇷🇴 Jaqueline Cristian (first round)

Qualifiers
• # 🇩🇪 Jule Niemeier

• # 🇵🇱 Magdalena Fręch

• # 🇯🇵 Misaki Doi

• # 🇺🇸 Asia Muhammad

• # 🇺🇸 Hailey Baptiste

• # 🇷🇺 Liudmila Samsonova