2021 WTA Lyon Open – Singles

World No. 139 Clara Tauson won her first WTA singles tennis title as a qualifier, defeating Viktorija Golubic in the final of the 2021 Lyon Open, 6–4, 6–1. Tauson did not drop a set throughout the entire tournament, including qualifying rounds, and dropped just 35 games across seven matches. Tauson became the second Danish player in history, after Caroline Wozniacki, to win a WTA Tour singles title. The final match was the first WTA singles final to be contested between two qualifiers since the 2017 Japan Women's Open.

Sofia Kenin was the defending champion, but chose not to participate after undergoing surgery for appendicitis.

Seeds
• #🇷🇺 Ekaterina Alexandrova (first round)

• #🇫🇷 Fiona Ferro (semifinals)

• #🇫🇷 Caroline Garcia (second round)

• #🇫🇷 Kristina Mladenovic (quarterfinals)

• #🇫🇷 Alizé Cornet (first round)

• #🇷🇴 Sorana Cîrstea (first round)

• #🇪🇸 Paula Badosa (semifinals)

• # Arantxa Rus (second round)

Seeds
• # 🇨🇿 Tereza Martincová (qualified)

• # 🇷🇺 Margarita Gasparyan (qualified)

• # Viktorija Golubic (qualified)

• # 🇧🇬 Viktoriya Tomova (qualifying competition)

• # Clara Tauson (qualified)

• # 🇦🇹 Barbara Haas (qualifying competition)

• # 🇬🇧 Harriet Dart (first round)

• # 🇷🇺 Kamilla Rakhimova (qualifying competition)

• # 🇷🇸 Olga Danilović (first round)

• #   Leonie Küng (qualifying competition)

• # 🇨🇳 Wang Xinyu (first round)

• # 🇷🇴 Jaqueline Cristian (first round)

Qualifiers
• # 🇨🇿 Tereza Martincová

• # 🇷🇺 Margarita Gasparyan

• #  Viktorija Golubic

• # 🇵🇱 Magdalena Fręch

• # Clara Tauson

• # 🇮🇹 Giulia Gatto-Monticone