2021 Winston-Salem Open

The 2021 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 52nd edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP Tour 250 Series of the 2021 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 21 through August 28, 2021. It was the last event on the 2021 US Open Series before the 2021 US Open.

Singles

 * 🇧🇾 Ilya Ivashka def. 🇸🇪 Mikael Ymer, 6–0, 6–2

Doubles

 * Marcelo Arévalo / Matwé Middelkoop def.  Ivan Dodig / 🇺🇸 Austin Krajicek, 6–7(5–7), 7–5, [10–6]

Prize money

 * per team

Seeds
1 Rankings are as of August 16, 2021

Other entrants
The following players received wildcards into the singles main draw:
 * 🇪🇸 Pablo Carreño Busta
 * 🇧🇪 David Goffin
 * 🇬🇧 Dan Evans
 * 🇬🇧 Andy Murray

The following player received entry using a protected ranking into the singles main draw:
 * 🇫🇷 Gilles Simon

The following players received entry from the qualifying draw:
 * 🇺🇸 Denis Kudla
 * 🇦🇺 Alexei Popyrin
 * 🇫🇷 Lucas Pouille
 * Wu Tung-lin

The following players received entry as lucky losers:
 * 🇫🇷 Pierre-Hugues Herbert
 * 🇺🇸 Eduardo Nava
 * 🇦🇺 Max Purcell
 * 🇺🇸 Noah Rubin
 * 🇯🇵 Yosuke Watanuki

Withdrawals

 * Before the tournament
 * Kevin Anderson → replaced by 🇫🇷 Arthur Rinderknech
 * 🇪🇸 Pablo Andújar → replaced by 🇮🇹 Marco Cecchinato
 * Nikoloz Basilashvili → replaced by 🇫🇷 Pierre-Hugues Herbert
 * Aljaž Bedene → replaced by 🇺🇸 Tennys Sandgren
 * 🇷🇸 Laslo Đere → replaced by 🇸🇪 Mikael Ymer
 * 🇧🇪 David Goffin → replaced by 🇺🇸 Eduardo Nava
 * Lloyd Harris → replaced by 🇸🇰 Norbert Gombos
 * 🇦🇺 Nick Kyrgios → replaced by 🇺🇸 Noah Rubin
 * 🇫🇷 Adrian Mannarino → replaced by 🇧🇷 Thiago Monteiro
 * 🇦🇺 John Millman → replaced by 🇦🇺 Max Purcell
 * 🇯🇵 Yoshihito Nishioka → replaced by 🇦🇷 Facundo Bagnis
 * 🇷🇸 Miomir Kecmanović → replaced by 🇲🇩 Radu Albot
 * 🇺🇸 Tommy Paul → replaced by 🇮🇹 Andreas Seppi
 * 🇮🇹 Lorenzo Sonego → replaced by 🇯🇵 Yosuke Watanuki

Seeds
1 Rankings are as of August 16, 2021

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇮🇳 Siddhant Banthia / 🇺🇸 Matthew Thomson
 * 🇺🇸 Nicholas Monroe / 🇺🇸 Jackson Withrow

Withdrawals

 * Before the tournament
 * Ivan Dodig / 🇬🇧 Jamie Murray → replaced by Ivan Dodig / 🇺🇸 Austin Krajicek
 * 🇪🇸 Marcel Granollers / 🇦🇷 Horacio Zeballos → replaced by 🇦🇹 Oliver Marach / 🇦🇹 Philipp Oswald
 * Wesley Koolhof / Jean-Julien Rojer → replaced by  Ariel Behar / 🇪🇨 Gonzalo Escobar
 * 🇩🇪 Kevin Krawietz / 🇷🇴 Horia Tecău → replaced by 🇧🇦 Tomislav Brkić / 🇷🇸 Nikola Ćaćić
 * 🇦🇺 John Peers / 🇸🇰 Filip Polášek → replaced by 🇳🇿 Marcus Daniell / 🇧🇷 Marcelo Demoliner
 * 🇩🇪 Tim Pütz / 🇳🇿 Michael Venus → replaced by 🇦🇺 Luke Saville / 🇦🇺 John-Patrick Smith
 * 🇺🇸 Rajeev Ram / 🇬🇧 Joe Salisbury → replaced by Marcelo Arévalo /  Matwé Middelkoop