2021 Winston-Salem Open – Doubles

Łukasz Kubot and Marcelo Melo were the reigning champions from when the tournament was last held in 2019, but lost in the semifinals to Ivan Dodig and Austin Krajicek.

Marcelo Arévalo and Matwé Middelkoop won the title, defeating Dodig and Krajicek in the final, 6–7(5–7), 7–5, [10–6].

Seeds
• # 🇵🇱 Łukasz Kubot / 🇧🇷 Marcelo Melo (semifinals)

• # 🇫🇷 Nicolas Mahut / 🇫🇷 Fabrice Martin (quarterfinals, withdrew)

• # Raven Klaasen / 🇯🇵 Ben McLachlan (first round)

• # 🇮🇹 Simone Bolelli / 🇦🇷 Máximo González (first round)