2021 Winston-Salem Open – Singles

Hubert Hurkacz was the reigning champion from when the tournament was last held in 2019, but chose not to participate this year.

Ilya Ivashka won his maiden ATP Tour title, defeating Mikael Ymer in the final, 6–0, 6–2. Ivashka became the first Belarusian man to win an ATP singles title since Max Mirnyi in 2003, while Ymer became the first Swedish man to reach an ATP singles final since Robin Söderling in 2011.

Seeds
All seeds receive a bye into the second round. • 🇪🇸 Pablo Carreño Busta (quarterfinals)

• 🇧🇪 David Goffin (withdrew)

• 🇬🇧 Dan Evans (third round)

• 🇭🇺 Márton Fucsovics (third round)

• 🇰🇿 Alexander Bublik (second round)

• Marin Čilić (second round)

• Nikoloz Basilashvili (withdrew)

• 🇦🇺 John Millman (withdrew)

• 🇩🇪 Jan-Lennard Struff (third round)

• 🇦🇷 Federico Delbonis (second round)

• 🇪🇸 Albert Ramos Viñolas (second round)

• 🇫🇷 Benoît Paire (third round)

• 🇺🇸 Frances Tiafoe (quarterfinals)

• 🇫🇷 Richard Gasquet (quarterfinals)

• 🇪🇸 Carlos Alcaraz (semifinals)

• 🇩🇪 Dominik Koepfer (third round)

Seeds
• # 🇦🇺 Alexei Popyrin (qualified)

• # 🇺🇸 Denis Kudla (qualified)

• # 🇫🇷 Pierre-Hugues Herbert (qualifying competition, lucky loser)

• # 🇫🇷 Lucas Pouille (qualified)

• # 🇦🇺 Max Purcell (qualifying competition, lucky loser)

• # 🇯🇵 Yosuke Watanuki (qualifying competition, lucky loser)

• # Wu Tung-lin (qualified)

• # 🇺🇸 Noah Rubin (qualifying competition, lucky loser)

Qualifiers
• # 🇦🇺 Alexei Popyrin

• # 🇺🇸 Denis Kudla

• # Wu Tung-lin

• # 🇫🇷 Lucas Pouille

Lucky losers
• # 🇯🇵 Yosuke Watanuki

• # 🇺🇸 Noah Rubin

• # 🇫🇷 Pierre-Hugues Herbert

• # 🇦🇺 Max Purcell

• # 🇺🇸 Eduardo Nava