2022–23 CAF Champions League knockout stage

The 2022–23 CAF Champions League knockout stage started on 21 April with the quarter-finals and ended on 11 June 2023 with the final to decide the champions of the 2022–23 CAF Champions League. A total of eight teams competed in the knockout stage.

Times were local.

Round and draw dates
The schedule was as follows.

Format
Each tie in the knockout phase was played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then extra time was not played and the winners were decided by a penalty shoot-out (Regulations III. 26 & 27).  The mechanism of the draws for each round was as follows:
 * In the draw for the quarter-finals, the four group winners were seeded, and the four group runners-up were unseeded. The seeded teams were drawn against the unseeded teams, with the seeded teams hosting the second leg. Teams from the same group cannot be drawn against each other, while teams from the same association can be drawn against each other.
 * In the draws for the semi-finals and final, there were no seedings, and teams from the same group or the same association could be drawn against each other. As the draws for the quarter-finals and semi-finals were held together before the quarter-finals were played, the identity of the quarter-final winners was not known at the time of the semi-final draw.

Qualified teams
The knockout stage involved the 8 teams which qualified as winners and runners-up of each of the eight groups in the group stage. 

Bracket
The bracket of the knockout stage was determined as follows:

 The bracket was decided after the draw for the knockout stage (quarter-finals, semi-finals and final), which was held on 5 April 2023, 18:30 GMT (20:30 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.



Quarter-finals
The draw for the quarter-finals was held on 5 April 2023.

Summary
The first legs were played on 21 and 22 April, and the second legs were played on 28 and 29 April 2023. 


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Matches
''1–1 on aggregate. Wydad AC won 4–3 on penalties.''

Al Ahly won 2–0 on aggregate.

Mamelodi Sundowns won 6–2 on aggregate.

Espérance de Tunis won 2–1 on aggregate.

Semi-finals
The draw for the semi-finals was held on 5 April 2023 (after the quarter-finals draw).

Summary
The first legs were played on 12 and 13 May, and the second legs were played on 19 and 20 May 2023. 


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Matches
Al Ahly won 4–0 on aggregate.

''2–2 on aggregate. Wydad AC won on away goals.''

Final
 The first leg was played on 4 June, and the second leg was played on 11 June 2023.


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Al Ahly won 3–2 on aggregate. 