2022–23 Southern Miss Lady Eagles basketball team

The 2022–23 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2022–23 NCAA Division I women's basketball season. The team was led by nineteenth-year head coach Joye Lee-McNelis, and played their home games at the Reed Green Coliseum in Hattiesburg, Mississippi as a member of the Sun Belt Conference.

The Lady Eagles finished as co-conference regular season champions with a record of 21–10 overall and 13–5 in conference play.

Previous season
The Lady Eagles finished 18–12 and 9–8 in conference-play for the 2021–22 basketball season. They lost in the conference tournament quarterfinal to, 50–70, and were unable to secure a bid into the NCAA tournament.

In March 2022, Southern Miss, as well as C-USA members Old Dominion and Marshall, announced that they would be joining the Sun Belt Conference effective July 1, 2022 to compete as full-time members for the 2022–23 season.

Schedule and results
!colspan=12 style=|Exhibition

!colspan=12 style=|Non-conference regular season

!colspan=12 style=|Sun Belt regular season

!colspan=12 style=| Sun Belt tournament


 * Source: Southern Miss Athletics