2022 AFC Champions League knockout stage

The 2022 AFC Champions League knockout stage was played from 18 August 2022 to 6 May 2023. A total of 16 teams competed in the knockout stage to decide the champions of the 2022 AFC Champions League.

Qualified teams
The group winners and three best runners-up in the group stage from each region advanced to the round of 16, with both West Region (Groups A–E) and East Region (Groups F–J) having eight qualified teams. 

Format
 In the knockout stage, the 16 teams played a single-elimination tournament, with the teams split into the two regions until the final. All ties were played as a single-leg match (Regulations Article 9.1), except for the final, which was played over two legs. Extra time and penalty shoot-out were used to decide the winners if necessary (Regulations Article 9.3 and 10.1). 

Schedule
The schedule of each round was as follows.

Bracket


Combination tables
 {{legend|#BBF3BB|Combination according to the three qualified teams}}  {{legend|#BBF3BB|Combination according to the three qualified teams}}
 * West Region
 * East Region

Summary
 The round of 16 was played over one leg, with the matchups determined by the combination tables based on which group runners-up qualified.


 * +West Region


 * +East Region



Summary
 The quarter-finals were played over one leg.


 * +West Region


 * +East Region



Summary
 The semi-finals were played over one leg.


 * +West Region


 * +East Region



Final
 The final was played over two legs.

Urawa Red Diamonds won 2–1 on aggregate.