2022 Ambato La Gran Ciudad – Singles

Thiago Agustín Tirante was the defending champion but lost in the semifinals to Facundo Bagnis.

Bagnis won the title after defeating João Lucas Reis da Silva 7–6(9–7), 6–4 in the final.

Seeds
• # 🇵🇪 Juan Pablo Varillas (semifinals)

• # 🇦🇷 Facundo Bagnis (champion)

• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇦🇷 Facundo Mena (quarterfinals)

• # 🇦🇷 Santiago Rodríguez Taverna (quarterfinals)

• # 🇦🇹 Gerald Melzer (first round)

• # 🇷🇸 Miljan Zekić (quarterfinals)

• # 🇦🇷 Thiago Agustín Tirante (semifinals)