2022 Amstelveen Women's Open – Singles

Quirine Lemoine was the defending champion but lost in the semifinals to Simona Waltert.

Waltert went on to win the title, defeating Emma Navarro in the final, 7–6(12–10), 6–0.

Seeds
• # Anastasia Tikhonova (first round)

• # Suzan Lamens (quarterfinals)

• # Joanne Züger (first round)

• # Simona Waltert (champion)

• # 🇧🇦 Dea Herdželaš (first round)

• # 🇪🇸 Aliona Bolsova (quarterfinals)

• # 🇨🇿 Sára Bejlek (semifinals)

• # 🇧🇬 Isabella Shinikova (second round)