2022 Andalucía Challenger – Men's singles

Gianluca Mager was the defending champion but chose not to defend his title.

Jaume Munar won the title after defeating Pedro Cachin 6–2, 6–2 in the final.

Seeds
• # 🇦🇹 Dominic Thiem (first round)

• # 🇸🇰 Alex Molčan (quarterfinals)

• # 🇪🇸 Pablo Andújar (semifinals)

• # 🇨🇿 Jiří Veselý (semifinals)

• # 🇪🇸 Roberto Carballés Baena (quarterfinals)

• # 🇪🇸 Jaume Munar (champion)

• # 🇮🇹 Marco Cecchinato (first round)

• # 🇪🇸 Carlos Taberner (second round)