2022 Arizona Tennis Classic – Singles

Denis Kudla defeated Daniel Altmaier in the final, 2–6, 6–2, 6–3, to win the singles tennis title at the 2022 Arizona Tennis Classic. It marked Kudla's eighth career ATP Challenger title.

Matteo Berrettini was the defending champion, but did not return to defend his title.

Seeds
• # 🇫🇷 Benoît Paire (second round)

• # 🇮🇹 Lorenzo Musetti (second round)

• # 🇫🇷 Arthur Rinderknech (second round)

• # 🇩🇪 Jan-Lennard Struff (first round)

• # 🇦🇷 Sebastián Báez (first round)

• # 🇫🇷 Hugo Gaston (first round)

• # 🇫🇮 Emil Ruusuvuori (second round)

• # 🇧🇪 David Goffin (quarterfinals)