2022 Atlanta Open – Singles

Alex de Minaur defeated Jenson Brooksby in the final, 6–3, 6–3 to win the singles title at the 2022 Atlanta Open. It was de Minaur's second Atlanta title, the first being in 2019.

John Isner was the defending champion, but lost in the quarterfinals to Brooksby.

Seeds
The top four seeds received a bye into the second round. • #🇺🇸 Reilly Opelka (withdrew)

• #🇺🇸 John Isner (quarterfinals)

• #🇦🇺 Alex de Minaur (champion)

• #🇺🇸 Frances Tiafoe (semifinals)

• #🇺🇸 Tommy Paul (quarterfinals)

• #🇺🇸 Jenson Brooksby (final)

• #🇦🇺 Nick Kyrgios (withdrew)

• #🇺🇸 Brandon Nakashima (quarterfinals)

Seeds
• # 🇫🇷 Adrian Mannarino (qualifying competition, lucky loser)

• # 🇦🇺 John Millman (moved to main draw)

• # 🇺🇸 Steve Johnson (qualifying competition, lucky loser)

• # 🇬🇧 Jack Draper (qualifying competition)

• # 🇩🇪 Peter Gojowczyk (qualified)

• # 🇯🇵 Taro Daniel (qualified)

• # 🇺🇸 Stefan Kozlov (first round)

• # 🇺🇸 J. J. Wolf (first round, retired)

Qualifiers
• # 🇯🇵 Taro Daniel

• # 🇩🇪 Dominik Koepfer

• # 🇩🇪 Peter Gojowczyk

• # 🇮🇳 Ramkumar Ramanathan

Lucky losers
• # 🇫🇷 Adrian Mannarino

• # 🇺🇸 Steve Johnson