2022 Australian Open – Girls' singles

Petra Marčinko defeated Sofia Costoulas in the final, 7–5, 6–1 to win the girls' singles title at the 2022 Australian Open.

Victoria Jiménez Kasintseva was the defending champion but chose not to participate, instead competing in the women's singles qualifying event, where she lost in the second round to Kamilla Rakhimova.

Angella Okutoyi and Meshkatolzahra Safi became the first girls of their countries to win a junior Grand Slam match, representing Kenya and Iran, respectively.

Seeds
• Petra Marčinko (champion)

• 🇷🇺 Diana Shnaider (quarterfinals)

• 🇷🇺 Ksenia Zaytseva (third round, retired)

• 🇦🇷 Solana Sierra (first round)

• 🇺🇸 Clervie Ngounoue (second round)

• Michaela Laki (quarterfinals)

•  Johanne Svendsen (first round)

• 🇧🇪 Sofia Costoulas (final)

•  Céline Naef (third round)

• 🇷🇺 Yaroslava Bartashevich (second round)

•  Lucija Ćirić Bagarić (first round)

• 🇧🇪 Hanne Vandewinkel (first round)

• 🇺🇸 Liv Hovde (semifinals)

• 🇨🇦 Victoria Mboko (second round)

• 🇫🇮 Laura Hietaranta (first round)

• 🇷🇺 Elena Pridankina (first round)

Seeds
• # 🇵🇱 Malwina Rowińska (qualifying competition)

• # 🇯🇵 Hayu Kinoshita (qualified)

• # 🇮🇹 Denise Valente (qualified)

• # Li Yu-yun (qualified)

• # 🇮🇹 Federica Urgesi (qualified)

• # 🇯🇵 Mio Mushika (qualified)

• # 🇦🇺 Zara Larke (qualified)

• # 🇦🇺 Anja Nayar (qualified)

• # 🇦🇺 Tianyu Dong (first round)

• # 🇦🇺 Stefani Webb (qualifying competition)

• # 🇦🇺 Darina Kamenoff (first round)

• # 🇦🇺 Sarah Rokusek (first round)

• # 🇦🇺 Elena Micic (qualified)

• # 🇦🇺 Mia Tsoukalas (first round)

• # 🇦🇺 Jelena Cvijanovic (qualifying competition)

• # 🇦🇺 Emerson Jones (qualifying competition)

Qualifiers
• # 🇦🇺 Elena Micic

• # 🇯🇵 Hayu Kinoshita

• # 🇮🇹 Denise Valente

• # Li Yu-yun

• # 🇮🇹 Federica Urgesi

• # 🇯🇵 Mio Mushika

• # 🇦🇺 Zara Larke

• # 🇦🇺 Anja Nayar