2022 Australian Open – Women's singles

Ashleigh Barty defeated Danielle Collins in the final, 6–3, 7–6(7–2) to win the women's singles tennis title at the 2022 Australian Open. It was her first Australian Open title and third and last major title overall. Barty became the first home player to win an Australian Open singles title since Chris O'Neil in 1978. Barty did not drop a set during the tournament. The final also marked Barty's last professional appearance, as she announced her retirement from the sport two months later.

Naomi Osaka was the defending champion, but lost to Amanda Anisimova in the third round.

Barty retained the world No. 1 singles ranking after Aryna Sabalenka and Barbora Krejčíková lost in the fourth round and quarterfinals, respectively. Collins entered the top 10 in the rankings for the first time by reaching the final.

Alizé Cornet reached her first major singles quarterfinal on her 63rd main-draw appearance, surpassing Tamarine Tanasugarn's all-time record, who reached her first quarterfinal at the 2008 Wimbledon Championships on her 45th attempt. Kaia Kanepi became the first Estonian to reach the quarterfinals at all four majors. For the first time since 1997, neither Venus nor Serena Williams participated in the Australian Open.

This was the last singles major for former world No. 4 and 2011 US Open champion Samantha Stosur, who announced her retirement from the discipline. She lost to Anastasia Pavlyuchenkova in the second round.

Seeds
• 🇦🇺 Ashleigh Barty (champion)

• 🇧🇾 Aryna Sabalenka (fourth round)

• 🇪🇸 Garbiñe Muguruza (second round)

• 🇨🇿 Barbora Krejčíková (quarterfinals)

• Maria Sakkari (fourth round)

• 🇪🇪 Anett Kontaveit (second round)

• 🇵🇱 Iga Świątek (semifinals)

• 🇪🇸 Paula Badosa (fourth round)

• 🇹🇳 Ons Jabeur (withdrew due to back injury)

• 🇷🇺 Anastasia Pavlyuchenkova (third round)

• 🇺🇸 Sofia Kenin (first round)

• 🇰🇿 Elena Rybakina (second round, retired)

• 🇯🇵 Naomi Osaka (third round)

• 🇷🇴 Simona Halep (fourth round)

• 🇺🇦 Elina Svitolina (third round)

• 🇩🇪 Angelique Kerber (first round)

•  Emma Raducanu (second round)

• 🇺🇸 Coco Gauff (first round)

• 🇧🇪 Elise Mertens (fourth round)

• 🇨🇿 Petra Kvitová (first round)

• 🇺🇸 Jessica Pegula (quarterfinals)

•  Belinda Bencic (second round)

• 🇨🇦 Leylah Fernandez (first round)

• 🇧🇾 Victoria Azarenka (fourth round)

• 🇷🇺 Daria Kasatkina (third round)

•  Jeļena Ostapenko (third round)

• 🇺🇸 Danielle Collins (final)

• 🇷🇺 Veronika Kudermetova (third round)

•  Tamara Zidanšek (third round)

• 🇮🇹 Camila Giorgi (third round)

• 🇨🇿 Markéta Vondroušová (third round)

• 🇪🇸 Sara Sorribes Tormo (second round)

Seeded players
The following are the seeded players. Seedings are based on WTA rankings as of 10 January 2022. Rank and points before are as of 17 January 2022.

Unlike in the men's tournament, points from the 2021 women's singles tournament will be dropped at the end of this year's tournament in addition to the 2020 women's singles tournament as player's points will also be dropped as usual. The "better of 2020/2021 points" for January, February and March were announced by the WTA in September 2021, even though the 2021 tournament was held three weeks later than in 2022. Accordingly, the higher of each player's 2020 or 2021 points will be replaced by her 2022 points at the end of the tournament.

† The player did not qualify for the tournament in either 2020 or 2021. Accordingly, points for her 16th best result are deducted instead.

Withdrawn players
The following players would have been seeded, but withdrew before the tournament began.

Wild cards
• 🇺🇸 Robin Anderson

• 🇦🇺 Priscilla Hon

• 🇦🇺 Maddison Inglis

• 🇫🇷 Diane Parry

• 🇦🇺 Storm Sanders

• 🇦🇺 Daria Saville

• 🇦🇺 Samantha Stosur

• 🇨🇳 Wang Xiyu

Protected ranking
• 🇧🇪 Kirsten Flipkens

• 🇩🇪 Tatjana Maria

Qualifiers
• 🇺🇸 Hailey Baptiste

• 🇺🇸 Emina Bektas

• 🇮🇹 Lucia Bronzetti

• 🇪🇸 Cristina Bucșa

• 🇬🇧 Harriet Dart

• 🇺🇸 Caroline Dolehide

• Arianne Hartono

• 🇰🇷 Jang Su-jeong

• 🇸🇰 Viktória Kužmová

• 🇨🇦 Rebecca Marino

• 🇧🇬 Viktoriya Tomova

• 🇮🇹 Martina Trevisan

• 🇺🇦 Lesia Tsurenko

•  Stefanie Vögele

• 🇺🇸 Katie Volynets

• 🇨🇳 Zheng Qinwen

Lucky losers
• 🇷🇴 Irina Bara

• 🇯🇵 Nao Hibino

Withdrawals
• † 🇺🇸 Serena Williams (41) → replaced by 🇰🇿 Zarina Diyas (103)

• † 🇨🇦 Bianca Andreescu (46) → replaced by 🇵🇱 Magdalena Fręch (104)

• & 🇨🇿 Karolína Plíšková (5) → replaced by 🇫🇷 Fiona Ferro (105)

• & 🇺🇸 Jennifer Brady (25) → replaced by 🇨🇳 Wang Qiang (106)

• & 🇨🇿 Karolína Muchová (32) → replaced by 🇯🇵 Misaki Doi (107)

• & 🇦🇷 Nadia Podoroska (83) → replaced by 🇫🇷 Harmony Tan (110)

• & 🇨🇳 Zheng Saisai (80) → replaced by 🇯🇵 Nao Hibino (LL)

• & 🇹🇳 Ons Jabeur (10) → replaced by 🇷🇴 Irina Bara (LL)

† – not included on entry list & – withdrew from entry list