2022 BOSS Open – Singles

Matteo Berrettini defeated Andy Murray in the final, 6–4, 5–7, 6–3 to win the singles tennis title at the 2022 Stuttgart Open.

Marin Čilić was the defending champion, but chose not to participate.

Seeds
The top four seeds receive a bye into the second round. • # Stefanos Tsitsipas (quarterfinals)

• # 🇮🇹 Matteo Berrettini (champion)

• # 🇵🇱 Hubert Hurkacz (second round)

• # 🇨🇦 Denis Shapovalov (second round)

• # Nikoloz Basilashvili (second round)

• # 🇮🇹 Lorenzo Sonego (quarterfinals)

• # 🇰🇿 Alexander Bublik (second round)

• # 🇫🇷 Ugo Humbert (first round)

Seeds
• # Aslan Karatsev (first round)

• # 🇫🇷 Quentin Halys (qualifying competition, retired)

• # 🇩🇪 Peter Gojowczyk (qualifying competition)

• # 🇩🇪 Yannick Hanfmann (first round)

• # 🇪🇸 Feliciano López (received wildcard to main draw)

• # 🇩🇪 Mats Moraing (qualifying competition)

• # 🇦🇺 Christopher O'Connell (qualified)

• # 🇲🇩 Radu Albot (qualified)

Qualifiers
• # Dominic Stricker

• # 🇲🇩 Radu Albot

• # 🇦🇺 Christopher O'Connell

• # 🇦🇹 Jurij Rodionov