2022 Boar's Head Resort Women's Open – Singles

Claire Liu was the defending champion but chose not to participate.

Louisa Chirico won the title, defeating Wang Xiyu in the final, 6–4, 6–3.

Seeds
• # 🇷🇴 Irina Bara (first round)

• # 🇩🇪 Tatjana Maria (semifinals)

• # 🇨🇳 Wang Xiyu (final)

• # 🇺🇸 Alycia Parks (first round)

• # 🇺🇸 Katie Volynets (second round)

• # 🇮🇹 Lucrezia Stefanini (semifinals)

• # 🇯🇵 Nao Hibino (second round)

• # 🇺🇸 Caroline Dolehide (first round)