2022 Brest Challenger – Singles

Brandon Nakashima was the defending champion but chose not to defend his title.

Grégoire Barrère won the title after defeating Luca Van Assche 6–3, 6–3 in the final.

Seeds
• # 🇫🇷 Benjamin Bonzi (second round, withdrew)

• # Nuno Borges (second round)

• # 🇫🇷 Grégoire Barrère (champion)

• # 🇫🇷 Hugo Grenier (first round)

• # Jelle Sels (quarterfinals)

• # 🇮🇹 Matteo Arnaldi (second round)

• # 🇫🇷 Geoffrey Blancaneaux (quarterfinals)

• # 🇫🇷 Manuel Guinard (quarterfinals)