2022 Caldas da Rainha Ladies Open – Singles

Zheng Saisai was the defending champion but chose not to participate.

Lucrezia Stefanini won the title, defeating Marina Bassols Ribera in the final, 3–6, 6–1, 7–6(7–3).

Seeds
• # Vitalia Diatchenko (quarterfinals)

• # 🇦🇺 Maddison Inglis (second round, retired)

• # Suzan Lamens (second round)

• # 🇯🇵 Mai Hontama (second round)

• # Lesley Pattinama Kerkhove (first round)

• # 🇬🇧 Yuriko Miyazaki (first round)

• # 🇪🇸 Marina Bassols Ribera (final)

• # 🇪🇸 Andrea Lázaro García (first round)