2022 Cali Open – Singles

This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito.

Facundo Mena won the title after defeating Miljan Zekić 6–2, 7–6(7–3) in the final.

Seeds
• # Tomás Barrios Vera (second round)

• # 🇦🇷 Facundo Mena (champion)

• # 🇦🇷 Juan Pablo Ficovich (second round)

• # 🇧🇷 Felipe Meligeni Alves (quarterfinals)

• # 🇦🇷 Francisco Comesaña (first round, retired)

• # 🇦🇹 Gerald Melzer (second round)

• # Gonzalo Lama (first round)

• # 🇷🇸 Miljan Zekić (final)