2022 Campeonato Internacional de Tênis de Campinas – Singles

Sebastián Báez was the defending champion but chose not to defend his title.

Jan Choinski won the title after defeating Juan Pablo Varillas 6–4, 6–4 in the final.

Seeds
• # 🇩🇪 Daniel Altmaier (first round)

• # 🇵🇪 Juan Pablo Varillas (final)

• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇦🇷 Camilo Ugo Carabelli (withdrew)

• # 🇦🇷 Juan Pablo Ficovich (first round)

• # 🇧🇷 Felipe Meligeni Alves (first round, retired)

• # 🇫🇷 Alexandre Müller (quarterfinals)

• # 🇦🇷 Facundo Mena (quarterfinals)