2022 Cary Challenger – Singles

Mitchell Krueger was the defending champion but lost in the first round to Keegan Smith.

Michael Mmoh won the title after defeating Dominik Koepfer 7–5, 6–3 in the final.

Seeds
• # 🇺🇸 Denis Kudla (semifinals)

• # 🇦🇺 Jordan Thompson (semifinals)

• # 🇺🇸 Stefan Kozlov (second round, retired)

• # 🇦🇷 Juan Pablo Ficovich (second round)

• # 🇦🇷 Facundo Mena (quarterfinals)

• # 🇦🇺 Aleksandar Vukic (first round)

• # 🇺🇸 Michael Mmoh (champion)

• # 🇩🇪 Dominik Koepfer (final)