2022 Challenger Città di Lugano – Singles

Dominic Stricker was the defending champion but lost in the first round to Jurij Rodionov.

Luca Nardi won the title after defeating Leandro Riedi 4–6, 6–2, 6–3 in the final.

Seeds
• # 🇺🇸 Maxime Cressy (first round)

• # 🇲🇩 Radu Albot (first round)

• # 🇩🇪 Mats Moraing (first round)

• # 🇫🇷 Pierre-Hugues Herbert (semifinals)

• # 🇧🇦 Damir Džumhur (second round)

• # 🇦🇹 Dennis Novak (first round)

• # 🇫🇷 Hugo Grenier (first round)

• # Dominic Stricker (first round)