2022 Challenger Ciudad de Guayaquil

The 2022 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the 18th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 31 October and 6 November 2022.

Seeds

 * 1 Rankings are as of 24 October 2022.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇪🇨 Andrés Andrade
 * 🇪🇨 Álvaro Guillén Meza
 * 🇪🇨 Cayetano March

The following player received entry into the singles main draw using a protected ranking:
 * 🇮🇳 Sumit Nagal

The following players received entry into the singles main draw as alternates:
 * 🇷🇸 Nikola Milojević
 * 🇪🇨 Roberto Quiroz
 * 🇪🇸 Nikolás Sánchez Izquierdo

The following players received entry from the qualifying draw:
 * 🇯🇲 Blaise Bicknell
 * 🇮🇹 Marco Cecchinato
 * 🇬🇧 Jan Choinski
 * 🇦🇷 Juan Ignacio Galarza
 * 🇧🇷 Eduardo Ribeiro
 * 🇧🇷 Thiago Seyboth Wild

The following player received entry as a lucky loser:
 * 🇦🇷 Román Andrés Burruchaga

Singles

 * 🇩🇪 Daniel Altmaier def. 🇦🇷 Federico Coria 6–2, 6–4.

Doubles

 * 🇦🇷 Guido Andreozzi / 🇦🇷 Guillermo Durán def. 🇦🇷 Facundo Díaz Acosta / 🇻🇪 Luis David Martínez 6–0, 6–4.