2022 Challenger Ciudad de Guayaquil – Singles

Alejandro Tabilo was the defending champion but chose not to defend his title.

Daniel Altmaier won the title after defeating Federico Coria 6–2, 6–4 in the final.

Seeds
• # 🇦🇷 Federico Coria (final)

• # 🇦🇷 Tomás Martín Etcheverry (first round)

• # 🇩🇪 Daniel Altmaier (champion)

• # 🇵🇪 Juan Pablo Varillas (semifinals)

• # 🇦🇷 Juan Manuel Cerúndolo (second round)

• # 🇮🇹 Franco Agamenone (second round)

• # 🇦🇷 Santiago Rodríguez Taverna (first round)

• # 🇧🇷 Felipe Meligeni Alves (second round)