2022 Challenger Coquimbo II – Singles

Facundo Díaz Acosta was the defending champion but lost in the final to Juan Manuel Cerúndolo.

Cerúndolo won the title after defeating Díaz Acosta 6–3, 3–6, 6–4 in the final.

Seeds
• # 🇦🇷 Federico Coria (quarterfinals)

• # 🇦🇷 Tomás Martín Etcheverry (quarterfinals)

• # 🇩🇪 Daniel Altmaier (first round)

• # 🇮🇹 Marco Cecchinato (quarterfinals)

• # 🇦🇷 Camilo Ugo Carabelli (second round)

• # 🇰🇿 Timofey Skatov (semifinals)

• # 🇦🇷 Juan Manuel Cerúndolo (champion)

• # 🇮🇹 Franco Agamenone (semifinals)